This paper explores the effect of cultural differences on bilateral trade for the cultural and creativeindustry. Empirical studies show, the more open the exporting country is, the more able it is to maintain selfuniqueness,and the higher its exportation of the cultural and creative bilateral trade is. There is no correlationbetween cultural differences and general trade of two countries. The greater the difference between the rivalcountries for the acceptance of different races, the higher the bilateral cultural and creative trade is. This finding showsit is important to retain the positive meaning and value in the cultural characteristics at the age of globalization, andthe uniqueness of the cultural and creative trade utterly different from the general trade.