Service outsourcing industry is high-tech, high value-added and high-end services and transfer of R & D of global industry structure upgrades the inevitable trend. This article, from the perspective of innovation of science and technology, selects 16 national innovation cities and service outsourcing model cities as the research sample. Through principal component analysis and stepwise regression, it is concluded that factors that impact the service outsourcing industry to upgrade the important innovation of science and technology include enterprise R&D expenditure for product sales income and GDP per capita, potentially driving tendency of the innovation of science and technology factors including college students enrollment, professional and technical personnel account for the proportion of expenditure on employment, R&D and GDP ratio. On this basis, this paper, by constructing a regression equation to calculate sensitivity analysis of the independent variable elasticity index, proposes that China tap the potential for professionals to increase the strength of investment in science and technology to promote the upgrade of the service outsourcing industry, according to the calculation results.