The Two FTZs in South America, Panama Colón Free Zone and Brazil Manaus Free Economic Zone, are the world's most successful FTZ practice models. Colón Free Zone is a typical coastal FTZ. It has a favorable geographical condition. It is implementing the most lax free-trade zone management, to become an international freight transshipment and shipping center in America. Manaus Free Economic Zone is a typical inland free trade zone. It has developed the inland outward processing trade center by tax and customs duty exemption and cut measures. The practice of Colón Free Zone has great reference for the construction of Shanghai Free Trade Zone and other applying coastal type FTZ in China. And the practice of Manaus Free Economic Zone has great reference value for the construction of inland free trade zones in China