Investor-State arbitration system, one of the main ways to settle investment disputes, not only plays an important role in TPP text but also may generate substantial and vital influence during the process of frequent trade among nations. The contents of the rules have been improved on the basis of the 2012 U.S. BIT model. Actually, TPP uses a variety of forms of restrictions on the jurisdiction of the arbitration tribunal, tries to balance the benefits between states and investors, takes into account the interests of developing countries and clears away all the obstacles for enforcement of investment arbitral awards. Facing the latest regulations on investor-state dispute settlement, it is necessary to take a set of essential corresponding measures, such as examining the difference and disparity between TPP and the legislative practice of Chinese treaties, keeping consummating domestic remedy system for investment disputes and enacting the state immunity law, in order to diminish negative impacts from TPP on China.