Since China’s accession to the WTO in 2001, China’s position in world trade and economy and global economic governance has greatly evolved. The multilateral trading system has achieved a lot while facing serious and fundamental challenges. Regional trade agreements, particularly the megaregionals have become the major approach for developed countries to promote global trade governance, which however is also facing counteraction of global structural adjustment, economic recession, and the anti-globalization sentiment. China has benefited a lot from WTO membership but not taken an active strategy in the involvement of WTO. Under the new circumstances, China should use the WTO as the prime platform and push forward the conclusion of Doha Round. At the same time, China should be open to various approaches to promote discussions and negotiations on new issues and take a targeted RTA strategy as to different partners to enhance China’s position in global trade governance.