Transportation cost is the biggest obstacle to the development of inland regions, which are far from the big center market. The disadvantage of geographical location is that the inland regions can only choose to replace the development strategy of the coastal region industry. In the case of these obstacles, it is difficult to completely overcome the problems faced by inland regional development merely by establishing a free trade zone. This paper argues that the inland free trade zone construction must be combined with the construction of inland port logistics and then the main task is to improve the relations between inland and coastal areas, inland and region center market, inland and market integration, and transportation mode innovation. Research results show that the infrastructure of China's inland free trade zones is not only lagging behind China’s coastal regions, but also far from good in comparison with developing countries in Asia. Therefore, investment in infrastructure construction is still an urgent task. The characteristics of China’s current free trade zones are more like investment facilitation test. Development of inland free trade should open wider in the future to adapt to the challenges of the change of global value chain. Inland industrial advantage should shift in the direction of the products’supply bases. Inland free trade zones should eventually become the leader in high-end industrial agglomeration, reform and innovation. Eventually, the rise of inland regions will have to be built on high value/weight ratios and services that do not depend on transport costs.