In spite of being a global trading power, the added value of China’s international trade is low, at the low end of the global value chain, therefore, the disadvantage of China’s international division of labor desperately needs to be changed. Global innovation chain is the new development, through which we may make use of global advanced knowledge, technology and information resources, improve the innovation ability, and promote upgrading of global value chain. China should accelerate the construction of global innovation chain, and strengthen the double spiral relationship between global innovation chain and global value chain, in order to improve the status of international division of labor by innovation.