In the context of the ever-increasing transnational mobility of production factors, the ability to attract and gather international talents has obviously become an important factor affecting a country’s open development and competitive advantage. This article attempts to measure the inflow of international talents by combining authoritative statistical data and manual data collection. On this basis, it uses transnational panel data to measure the actual impact of the business environment on the transnational talent flow. The results found: First, the optimization of the business environment does have a positive effect on attracting international talent inflow. Second, the above conclusion is still valid after controlling for other possible influencing factors and a series of robustness tests. Third, the business environment characterized by the two dimensions of economic factor environment and social legal environment has a significantly higher impact on the inflow of international talents than the business environment characterized by the two dimensions of production factor market environment and infrastructure environment . At present, China's opening strategy is in an important stage of transformation, which includes the implementation of the talent internationalization strategy and the expansion of opening up measures to optimize the business environment. The findings of this article not only provide empirical evidence support for the above-mentioned strategic transformation from a specific level, but also have important policy implications for how to optimize the business environment in the new stage to better implement the talent internationalization strategy to promote the high-quality development of the open economy .