The novel coronavirus pneumonia epidemic will accelerate the transfer of world’s power center. With the changed content of global trade governance and the more prominent deficit of trade governance, new governance concepts, entities and objectives are needed to adapt to the new development of trade liberalization in the post epidemic era. In order to comprehend break and establish as well as to substitute and complement the international trade rule in the post epidemic era, it is necessary to learn from history and follow the rule, deeply excavate the theoretical logic behind global trade governance, view history from a development perspective, support concentration with the invariance of multilateralism, and maintain vitality with new developments in trade governance. China is paying more and more attention to the governance of global trade, actively implementing the governance concept with Chinese characteristics, promoting community of destiny, institution, interests as well as responsibilities with other countries, and contributing Chinese power and wisdom to the reform of the global trade governance system in the post-epidemic era.