The Indo-Pacific Economic Framework is a non-traditional economic and trade agreement formulated by the United States to make up for the economic shortcomings of the Indo-Pacific Strategy. In terms of agenda setting, it focuses on the emerging economic field, aiming to ensure the dominance of the United States in the competition in key fields, and realize the goal of carrying out geo-economic containment against China to return to the economic cooperation mechanism in the Asia-Pacific Region. Although the effectiveness of the Indo-Pacific Economic Framework remains to be seen, due to its obvious strategic implications for China, it may have an impact on emerging industries such as China’s digital economy, infrastructure construction and manufacturing in the Belt and Road Initiatives, China’s supply chain system, legitimate economic activities of the enterprise and voice in the Asia-Pacific Region. Therefore, China should accelerate reform by opening up and promote bilateral, regional and multilateral economic cooperation among Asia-Pacific countries. Besides, China should strengthen its ability to construct rules to enhance its voice and better cope with the Indo-Pacific Economic Framework.